Abstract:

Contrary to common thought, the breast cancer invasion front is not a homogenous interface. At the micron-scale, pioneer groups of cancer cells infiltrate into the mammary tissue. To recapitulate these events, a laser-based bioprinter was utilized to print spatially-defined co-culture patterns of breast cancer cells and fibroblasts. Migratory potential of breast cancer cells were measured as a function of pattern spacing and configuration. Results indicate that in the presence of fibroblasts directs cancer migration preferentially towards neighboring stromal (non-cancer) cells over 3 days in culture.

- Theresa Phamduy

Collaborators:

Matthew E. Burrow, Ph.D. (Burrow Lab)
Molecular and Cellular Oncology Laboratory, Tulane Univeristy