Cytotoxicity of Breast Cancer Cells via RF Thermablation

Investigating the cytotoxicity of magnetic nanoparticles exposed to breast cancer cells in 3-D in vitro environments

Breast Cancer Cells

Abstract:

Recent studies have shown promising potential for targeted magnetic nano-structured materials to induce localized thermoablation as therapies against breast cancer. When exposed to a radiofrequency inductive field (RF, 50-100 kHz), ferric oxide magnetic nanoparticles (Fe3O4 MNPs) resonate with the field and generate friction, delivering a potentially cytotoxic dose of thermal energy to the targeted cancer cells and causing magnetically-induced hyperthermia. This study aims to observe the targeting ability and specificity of endocytosis-inducing peptide-conjugated onto SiO2 (Silicon Dioxide) coated Fe3O4 nanoparticles. In addition, cytotoxicity studies will determine the effectiveness of the MNPs against breast cancer cell lines, MCF-7 and MDA-MB-231, in 3-D hydrogel (alginate) microenvironments.

- Courtney Evans